Degenerative Myleopathy - progressive disease of the spinal cord. Degenerative Myelopathy (DM) is a fatal, neurodegenerative disease showing a lack of coordination of muscle movements in the pelvic limbs. Dogs diagnosed with DM have degeneration of the spinal cord. When muscles no longer receive the messages from the motor neurons that they require to function, the muscles begin to atrophy (become smaller). Limbs look "thinner" as muscle tissue atrophies. In end stages of the disease, limbs may become paralyzed. DM affects adult dogs typically over the age of 8 years and there are Alaskan Malamutes diagnosed with it. A DNA test is available for use by anyone. Having two mutated copies of the gene does not necessarily result in disease, particularly since many dogs die of 'other things' prior to the disease developing.

Alaskan Malamute Polyneuropathy - DNA test for polyneuropathy to be commercially available 2012*

Cone Degeneration - day blindness. The OptiGen “CD” test is a DNA based test that provide a method to identify Cone Degeneration Disease (CD) in the the Alaskan Malamute (and German Shorthaired Pointer). Although the disease is rare, it is important to control the gene frequency so as to prevent producing puppies affected with the disease. CD disease causes day blindness due to degeneration of the retinal “cones” – cone-shaped cells in the retina that respond primarily to bright daylight. While CD can be diagnosed by exam in the early weeks of the affected dog’s life, carriers require a DNA test. The pups become day-blind and are photophobic – meaning that exposure to bright light is irritating or even painful. CD does not affect night vision. 

Multidrug Resistance (MDR1 mutation) - moderate to severe allergic reaction to certain tranquilizers, antibiotics, anti-cancer and pain control drugs. My first Malamute was profoundly affected by many of these drugs I've listed here - but there wasn't any 'DNA test' at that point. Acepromazine (tranquilizer and pre-anesthetic agent); Butorphanol (analgesic and pre-anesthetic agent); Emodepside (Profender®)-is a deworming drug; Erythromycin; Ivermectin (antiparasitic agent); Loperamide (ImodiumTM; antidiarrheal agent); Selamectin, milbemycin, and moxidectin (antaparasitic agents); Vincristine, Vinblastine, Doxorubicin (chemotherapy agents). Cyclosporin (immunosuppressive agent); Digoxin (cardiac drug); Doxycycline (antibacterial drug). Morphine, buprenorphine, fentanyl (opioid analgesics or pain medications).

* Carrier, or even affected, can be bred - harmlessly - to NON-CARRIER and NON-AFFECTED, thus, eliminating the disease without continuing it.